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Aspirin is rapidly absorbed and almost totally hydrolyzed to salicylic acid following oral administration. Although [link widoczny dla zalogowanych] has a half-life of only about 15 minutes, the apparent biologic half-life of salicylic acid in the therapeutic plasma concentration range is between 6 and 12 hours. Salicylic acid is eliminated by renal excretion and by biotransformation to inactive metabolites. Clearance of salicylic acid in the high-dose range is sensitive to urinary pH (see [link widoczny dla zalogowanych] Interactions ) and is reduced by renal dysfunction.